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PseudoUridines Make Critical Contributions to mRNA Vaccines

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PseudoUridines Make Critical Contributions to mRNA Vaccines

February 21
23:21 2022
BOC Sciences becomes one of the participants and contributors in the campaign against COVID-19 for its pseudoUridines and derivatives greatly speed up vaccine development.

New York, USA – February 21, 2022 – The current COVID-19 pandemic has brought about millions of deaths since its outbreak in 2020, desperately requiring the emergence of effective vaccines. Two vaccines, based on mRNA techniques, were contrived by Pfizer-BioNTech and Moderna Therapeutics and both showed efficacy higher than 90%. These striking accomplishments could be attributed to the RNA modification (N1-methyl-pseudoUridine), without which the Curevac mRNA vaccine (CVnCoV) presents a much lower efficacy of 48%.

Along with the growing demands on vaccine raw material pseudoUridine (Ψ), BOC Sciences, in possession of advanced equipment and rich experience, gradually rises to be a recognized supplier. It can yield pseudoUridines surpassing 500 kg annually, which makes it the largest manufacturer in this field.

BOC Sciences owns such a long pseudoUridine product catalog that aside from pseudoUridines, contains numerous related derivatives. Modified pseudoUridines, phosphate pseudoUridines, and phosphoramidite pseudoUridines of BOC Sciences are all enjoying increasing popularity among vaccine manufacturers. Some of BOC Sciences’ partners such as Moderna, the renowned mRNA developer, have used pseudouracil modification to maintain mRNA stability in COVID-19 vaccines.

The most attention-getting product of BOC Sciences is the 1-methylpseudoUridine (m1Ψ) which belongs to the modified pseudoUridine and has been proved ever so advantageous for developing mRNA vaccines. The existed research reveals that the m1Ψ can improve mRNA stability and mitigate anti-mRNA immune response, thereby promoting the improvements of mRNA therapeutics especially mRNA vaccines that are essential for combating COVID-19.

Other types of pseudoUridines are available at BOC Sciences, displaying similar roles as m1Ψ in modifying mRNA. For instance, the pseudoUridine 5′-triphosphate is employed to reduce the immune toxicity of mRNA therapy in the host while RNA phosphoramidites serve as building blocks in the chemical synthesis of oligonucleotides to exhibit effects on RNA structure and stability. Customers are allowed to personalize their selection of pseudoUridines in the light of specific applications. Further, the professional staff of BOC Sciences is always on call to give consultations.

BOC Sciences is a responsible entity that devotes itself to not only commercial production but also industry communication. In the recent webinar held on January 19th, 2022, BOC Sciences invited Dr. Rouskin from Harvard Medical School to navigate interested students or researchers through her findings of RNA structure and corresponding therapeutic strategies. For anyone still desiring the informative meeting, BOC Sciences provides the video here: https://nucleotech.bocsci.com/webinar-targeting-rna-structure-as-a-therapeutic-strategy.html.

About

BOC Sciences is an honored pseudoUridine supplier due to its potent productivity and strict quality control. Its yearly output of pseudoUridines has reached 500 kg, a stunning number that manifests BOC Sciences’ robust manufacturing capacity. After years of devotion, it undoubtedly grows to be the number one in pseudoUridine production.

Media Contact
Company Name: BOC Sciences
Contact Person: Alex Brown
Email: Send Email
Phone: 1-631-485-4226
Country: United States
Website: https://nucleotech.bocsci.com

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