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The PCSK9 Inhibitors Market Insights report from DelveInsight provides a thorough understanding of the PCSK9 Inhibitors Market size by treatment, epidemiology, emerging therapies, PCSK9 Inhibitors market share of the various therapies, and the current and forecasted PCSK9 Inhibitors Market size from 2019 to 2032 divided into the 7MM (the USA, EU5 (Germany, France, Italy, Spain, and the UK), and Japan) regions.

PCSK9 Inhibitors: An Overview

Proprotein convertase subtilisin/Kexin type 9 (PCSK9) regulates low-density lipoprotein (LDL) receptor degradation and reduces the clearance of circulating LDL particles, which is important in cholesterol metabolism. PCSK9 is primarily produced by hepatocytes, with the intestines and kidneys serving as secondary sources. PCSK9 decreases the number of LDLR in hepatocytes by promoting their metabolism and subsequent destruction, preventing the receptors from being broken down and allowing them to continue to lower blood cholesterol. PCSK9 inhibitors indications include familial hypercholesterolemia patients who are resistant to statins or have increased LDL-C levels while being on maximally tolerated statin therapy. The PCSK9 inhibitors are also approved for the treatment of existing cardiovascular disease to minimize the risk of myocardial infarction, stroke, and coronary revascularization.

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Regions Covered in the PCSK9 Inhibitors Market Report

• The United States
• EU5 (Germany, France, Italy, Spain, and the United Kingdom)
• Japan

Key Takeaways from PCSK9 Inhibitors Market Report

• According to DelveInsight estimates, the PCSK9 Inhibitors market size in the 7MM was found to be approximately USD 1.1 billion in 2021.
• As per the analysis, the total number of Familial Hypercholesterolemia prevalent cases in the 7MM was approximately 3.1 million in 2021.
• PCSK9 Inhibitors market is expected to grow significantly owing to the use of PCSK9 inhibitors in statin-intolerant patients, promising future strategies of PCSK9 inhibition, implications of PCSK9 inhibitors in broader therapy areas, and PCSK9 inhibition in a prophylactic setting, which can relieve the CVD burden.

PCSK9 Inhibitors Epidemiology Insights

Among the PCSK9 inhibitors list, there are three drugs, Repatha (evolocumab), Leqvio (inclisiran) and Praluent (alirocumab), and others are being developed at the moment. The most common PCSK9 Inhibitors side effects are minor. They include back pain and cold or flu symptoms as it is administered as a PCSK9 Inhibitor injection. These PCSK9 Inhibitor drugs may also cause allergic reactions in certain persons.

PCSK9 Inhibitors Epidemiology Segmentation in the 7MM

• Total Prevalent Cases of Familial Hypercholesterolemia
• Total Diagnosed Cases of Familial Hypercholesterolemia
• Type-specific Cases of Familial Hypercholesterolemia
• Age group-specific Cases of Familial Hypercholesterolemia
• Mutation-specific Cases of Familial Hypercholesterolemia
• Risk factor-specific Cases of PCSK9 Inhibitors in Prophylactic/Preventive setting
• Total Treated Cases of PCSK9 Inhibitors

PCSK9 Inhibitors Market Insights

Monoclonal antibodies directed at PCSK9 are the first to be approved. There are currently two FDA approved PCSK9 inhibitors namely, alirocumab and evolocumab available in the United States for adult patients to reduce the risk of myocardial infarction, stroke, and unstable angina requiring hospitalization in adults with established cardiovascular disease as an adjunct to diet, alone or in combination with other lipid-lowering therapies, for the treatment of adults with primary hyperlipidemia (including HeFH) to reduce LDL-cholesterol. Evolocumab is also approved as an adjuvant to diet and other LDL-reducing treatments in individuals with HoFH who require further LDL-C reduction. The mAb PCSK9 inhibitors evolocumab and alirocumab reduce LDL-C levels by roughly 60% when combined with statin treatment and reduce the risk of severe vascular events. Both of these PCSK9 Inhibitors drugs have the same PCSK9 Inhibitors mechanism of action. In addition, large PCSK9 Inhibitors trials have demonstrated that PCSK9 inhibitors, when added to the statin-based treatment, cut ASCVD risk even more, and their usage may need to be restricted to individuals at greatest risk for ASCVD.

PCSK9 Inhibitors Companies

• LIB Therapeutics
• AstraZeneca and Ionis Pharmaceuticals
• CiVi Biopharma, and Several Others

PCSK9 Inhibitors Drugs

• LIB003 (Lerodalcibep)
• AZD8233 (ION449)
• Cepadacursen sodium (CIVI-007)
• CiVI-008, and several others

PCSK9 Inhibitors Market Dynamics

The PCSK9 Inhibitors market dynamics is expected to change in the coming years due to several factors such as the improvement in the rise in the number of healthcare spending globally and rising cases of statin resistance in patients with familial hypercholesterolemic as well increasing risk of cardiovascular conditions such as myocardial infarction, coronary revascularization etc. Furthermore, the PCSK9 inhibition in a prophylactic setting can relieve the CVD burden and thus impacting the PCSK9 Inhibitors market positively. In addition, the implications of PCSK9 inhibitors in broader therapy areas also contribute towards the growth of the PCSK9 Inhibitors market. Though monoclonal antibodies have, for the time being, established themselves as the most clinically useful inhibitors of PCSK9, other novel therapies are currently in various stages of development and will be available soon in the PCSK9 Inhibitors market.

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Table of Content

1. Key Insights
2. PCSK9 Inhibitors Executive Summary
3. Competitive Intelligence Analysis
4. PCSK9 Inhibitors Market Overview at a Glance
5. PCSK9 Inhibitors Disease Background and Overview
6. Patient Journey
7. PCSK9 Inhibitors Epidemiology and Patient Population
8. PCSK9 Inhibitors Treatment Algorithm, Current Treatment, and Medical Practices
9. Unmet Needs
10. Key Endpoints of PCSK9 Inhibitors Treatment
11. PCSK9 Inhibitors Marketed Products
12. PCSK9 Inhibitors Emerging Therapies
13. PCSK9 Inhibitors: Seven Major Market Analysis
14. Attribute analysis
15. 7MM: PCSK9 Inhibitors Market Outlook
16. Access and Reimbursement Overview of PCSK9 Inhibitors
17. KOL Views
18. PCSK9 Inhibitors Market Drivers
19. PCSK9 Inhibitors Market Barriers
20. Appendix
21. DelveInsight Capabilities
22. Disclaimer
23. About DelveInsight

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